Structure of PDB 8tbu Chain G

Receptor sequence
>8tbuG (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]
ELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASR
SVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYR
PVAIALDTKGPELPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVR
AALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEK
VFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDG
ADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLS
RDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTR
SAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRV
GDLVIVVTGWRPGSGYTNIMRVLSIS
3D structure
PDB8tbu Structure-Based Design of AG-946, a Pyruvate Kinase Activator.
ChainG
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PYR G K313 A336 G338 D339 T371 K165 A188 G190 D191 T223
BS02 FBP G L474 T475 T476 T477 S480 W525 R532 G557 R559 P560 G561 S562 G563 Y564 T565 L326 T327 T328 T329 S332 W377 R384 G409 R411 P412 G413 S414 G415 Y416 T417
BS03 MN G E315 D339 E167 D191
BS04 I0R G F69 L70 Q436 F20 L21 Q288
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
Biological Process
GO:0001666 response to hypoxia
GO:0006096 glycolytic process
GO:0007584 response to nutrient
GO:0009749 response to glucose
GO:0010038 response to metal ion
GO:0016310 phosphorylation
GO:0032869 cellular response to insulin stimulus
GO:0033198 response to ATP
GO:0042866 pyruvate biosynthetic process
GO:0051591 response to cAMP
GO:0071872 cellular response to epinephrine stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tbu, PDBe:8tbu, PDBj:8tbu
PDBsum8tbu
PubMed38109501
UniProtP30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)

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