Structure of PDB 8r4o Chain G

Receptor sequence
>8r4oG (length=323) Species: 9606 (Homo sapiens) [Search protein sequence]
RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF
REVQIMKMLSHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMA
EKEARRKFKQIVTAVYFCHSRNIVHRDLKAENLLLDANLNIKIADFGFSN
LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL
PFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQI
CKHKWMKLGDADPNFDRLIAESQQLKEERQVDPLNEDVLLAMEDMGLDKE
QTLQSLRSDAYDHYSAIYSLLCD
3D structure
PDB8r4o The structures of salt inducible kinase 3 in complex with pharmacological inhibitors reveal determinants for binding and selectivity.
ChainG
Resolution2.725 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XVI G I72 G75 V80 A93 K95 T142 Y144 A145 G148 L195 A205 D206 I11 G14 V19 A32 K34 T81 Y83 A84 G87 L134 A144 D145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8r4o, PDBe:8r4o, PDBj:8r4o
PDBsum8r4o
PubMed38508313
UniProtQ9Y2K2|SIK3_HUMAN Serine/threonine-protein kinase SIK3 (Gene Name=SIK3)

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