Structure of PDB 8r3s Chain G

Receptor sequence
>8r3sG (length=662) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
FNEKDQLAVDTLRALSIDTIEKANSGHPGLPMGAAPMAYTLWTRHLNFNP
QSKDYFNRDRFVLSAGHGSALLYSLLHVSGSLELEELKQFRQWGSKTPGH
PEYRHTDGVEVTTGPLGQGFAMSVGLALAEDHLAGKFNKEGYNVVDHYTY
VLASDGDLMEGISHEAASFAGHNKLSKLVVLYDSNDISLDGELNKAFSEN
TKARFEAYGWNYLLVKDGNDLEEIDKAITTAKSQEGPTIIEVKTTIGFGS
PNKAGTNGVHGAPLGEVERKLTFENYGLDPEKRFNVSEEVYEIFQNTMLK
RANEDESQWNSLLEKYAETYPELAEEFKLAISGKLPKNYKDELPRFELGH
NGASRADSGTVIQAISKTVPSFFGGSADLAGSNKSNVNDATDYSSETPEG
KNVWFGVREFAMGAAVNGMAAHGGLHPYGATFFVFSDYLKPALRLSSIMG
LNATFIFTHDSIAVGEDGPTHEPIEQLAGLRAIPNMNVIRPADGNETRVA
WEVALESESTPTSLVLTRQNLPVLDVPEDVVEEGVRKGAYTVYGSEETPE
FLLLASGSEVSLAVEAAKDLEKQGKSVRVVSMPNWNAFEQQSEEYKESVI
PSSVTKRVAIEMASPLGWHKYVGTAGKVIAIDGFGASAPGDLVVEKYGFT
KENILNQVMSLE
3D structure
PDB8r3s Are Transketolases relevant Targets fighting Human Pathogens? A comparative Biochemical, Bioinformatic and Structural Study
ChainG
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.1: transketolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP G H68 G115 L117 S155 D156 G157 N186 I188 S189 L190 H261 H67 G114 L116 S154 D155 G156 N185 I187 S188 L189 H260
BS02 MG G D156 N186 I188 D155 N185 I187
BS03 TPP G E410 F436 Y439 E409 F435 Y438
Gene Ontology
Molecular Function
GO:0004802 transketolase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0006310 DNA recombination
GO:0019253 reductive pentose-phosphate cycle
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r3s, PDBe:8r3s, PDBj:8r3s
PDBsum8r3s
PubMed
UniProtP99161|TKT_STAAN Transketolase (Gene Name=tkt)

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