Structure of PDB 8qns Chain G

Receptor sequence

>8qnsG (length=440) Species: 10090 (Mus musculus)

APSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSK
ELWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGVAV
LTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEV
KSRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQASG
IEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGG
RLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAEL
QARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYW
HQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKAEDYGKGVIFYLRDKVV
VGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED

3D structure

• PDB: 8qns Structural characterization of the interaction between apoptosis inducing factor (AIF) and CHCHD4.
• Chain: G
• Resolution: 3.206 Å

Enzymatic activity

• Enzyme Commision number: 1.6.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	G	Y346 S499 S500 L501 P502 T503 V504 G505 V506 F507 A508 K509 E557 D558 Y559 E602 K605	Y220 S373 S374 L375 P376 T377 V378 G379 V380 F381 A382 K383 E385 D386 Y387 E430 K433
BS02	FAD	G	G137 G138 G139 T140 A141 E163 R171 P172 K176 K231 V232 T259 G260 R284 E404 G436 D437 E452 H453 H454 F481 W482	G11 G12 G13 T14 A15 E37 R45 P46 K50 K105 V106 T133 G134 R158 E278 G310 D311 E326 H327 H328 F355 W356
BS03	NAD	G	L266 G306 G307 G308 F309 L310 E313 E335 K341 A396 V397 G398 L399 E452 H453 W482	L140 G180 G181 G182 F183 L184 E187 E209 K215 A270 V271 G272 L273 E326 H327 W356

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0046983 protein dimerization activity

External links

• PDB: RCSB:8qns, PDBe:8qns, PDBj:8qns
• PDBsum: 8qns
• UniProt: Q9Z0X1|AIFM1_MOUSE Apoptosis-inducing factor 1, mitochondrial (Gene Name=Aifm1)