Structure of PDB 8qjr Chain G

Receptor sequence
>8qjrG (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVD
FKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSV
FTSVRQKIEK
3D structure
PDB8qjr PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
ChainG
Resolution3.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VLH G V1484 F1485 L1488 P1489 Y1497 A1536 F1539 N1540 V28 F29 L32 P33 Y41 A80 F83 N84
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0016586 RSC-type complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8qjr, PDBe:8qjr, PDBj:8qjr
PDBsum8qjr
PubMed38180485
UniProtP51532|SMCA4_HUMAN Transcription activator BRG1 (Gene Name=SMARCA4)

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