Structure of PDB 8om1 Chain G

Receptor sequence

>8om1G (length=689) Species: 10090 (Mus musculus) [Search protein sequence]

ASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRM
CLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLD
CPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCI
QCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNVIDICP
VGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRM
HEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVA
GMLQNFEGNAVAAIAGGLVDAEALVALKDLLNKVDSDNLCTEEIFPTEGA
GTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDL
KVALIGSPVDLTYRYDHLGDSPKILQDIASGRHSFCEVLKDAKKPMVVLG
SSALQRDDGAAILVAVSNMVQKIRVTTGVAAEWKVMNILHRIASQVAALD
LGYKPGVEAIRKNPPKMLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGA
PMADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALS
EIAGITLPYDTLDQVRNRLEEVSPNLVRYDDIEETNYFQQASELAKLVNQ
EVLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTE

3D structure

PDB

8om1 Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I.

Chain

Resolution

2.39 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	SF4	G	H101 D104 C105 C108 Q110 G111 C114 L116 Q117 V205	H97 D100 C101 C104 Q106 G107 C110 L112 Q113 V201
BS02	SF4	G	C153 I154 Q155 C156 T157 R158 C159 V183 C203 P204 A207 L208	C149 I150 Q151 C152 T153 R154 C155 V179 C199 P200 A203 L204
BS03	FES	G	R39 C41 Y42 G50 C52 R53 C55 C69	R35 C37 Y38 G46 C48 R49 C51 C65

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0009060	aerobic respiration
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:0042773	ATP synthesis coupled electron transport
GO:0042776	proton motive force-driven mitochondrial ATP synthesis
GO:0045333	cellular respiration
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0016020	membrane
GO:0043209	myelin sheath
GO:0045271	respiratory chain complex I

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8om1, PDBe:8om1, PDBj:8om1
PDBsum	8om1
PubMed	37531432
UniProt	Q91VD9\|NDUS1_MOUSE NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (Gene Name=Ndufs1)

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