Structure of PDB 8jpc Chain G

Receptor sequence
>8jpcG (length=658) Species: 9913 (Bos taurus) [Search protein sequence]
ADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRG
EVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEER
LVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIE
EICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGG
FGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC
PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEPDMIFYAAEI
ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV
GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE
IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESP
FFRDLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDS
DQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEE
DYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLL
TMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAY
REAQQLVQ
3D structure
PDB8jpc GPCR activation and GRK2 assembly by a biased intracellular agonist.
ChainG
Resolution3.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.15: [beta-adrenergic-receptor] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRW G L4 E5 L3 E4
BS02 STU G I197 G198 V205 A218 K220 D272 L273 M274 L324 I196 G197 V204 A217 K219 D271 L272 M273 L323
Gene Ontology
Molecular Function
GO:0001664 G protein-coupled receptor binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G protein-coupled receptor kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031694 alpha-2A adrenergic receptor binding
GO:0031755 Edg-2 lysophosphatidic acid receptor binding
GO:0047696 beta-adrenergic receptor kinase activity
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0002029 desensitization of G protein-coupled receptor signaling pathway
GO:0002031 G protein-coupled receptor internalization
GO:0003108 negative regulation of the force of heart contraction by chemical signal
GO:0006468 protein phosphorylation
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0009966 regulation of signal transduction
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045988 negative regulation of striated muscle contraction
GO:0060048 cardiac muscle contraction
GO:1901081 negative regulation of relaxation of smooth muscle
GO:1903566 positive regulation of protein localization to cilium
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042995 cell projection
GO:0045202 synapse
GO:0098793 presynapse
GO:0098794 postsynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jpc, PDBe:8jpc, PDBj:8jpc
PDBsum8jpc
PubMed37532940
UniProtP21146|ARBK1_BOVIN Beta-adrenergic receptor kinase 1 (Gene Name=GRK2)

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