Structure of PDB 8jnk Chain G

Receptor sequence
>8jnkG (length=201) Species: 9606 (Homo sapiens) [Search protein sequence]
VIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLSQDVPWKQRTG
IREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTG
HTFNSLLCNLYRNEKDSVDWHSDDCPSLGRSPIIASLSFGATRTFEMRKK
PPPVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVY
P
3D structure
PDB8jnk The Molecular Basis of Human ALKBH3 Mediated RNA N1-methyladenosine (m1A) Demethylation
ChainG
Resolution2.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
1.14.11.54: mRNA N(1)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna G R122 E123 Y127 P130 R131 Y141 K185 V188 D189 H191 C195 K261 Y263 R52 E53 Y57 P60 R61 Y71 K115 V118 D119 H121 C125 K183 Y185
BS02 MN G H191 D193 H257 H121 D123 H179
Gene Ontology
Molecular Function
GO:0051213 dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8jnk, PDBe:8jnk, PDBj:8jnk
PDBsum8jnk
PubMed38158383
UniProtQ96Q83|ALKB3_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Gene Name=ALKBH3)

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