Structure of PDB 8j6n Chain G

Receptor sequence
>8j6nG (length=389) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GFLPSFQHFATQAIHVGQEPEQWSSRAVVLPISLATTFKQDSPGQSSGFV
YSRSGNPTRNCLEKAVAALDGAKHCLTFASGLAATTTITHLLKAGDEVIC
MDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETP
TNPTLKLADIKACAQIVHKHKDIILVVDNTFMSAYFQRPLALGADICMCS
ATKYMNGHSDVVMGLVSVNSDDLNERLRFLQNSLGAVPSPFDCYLCCRGL
KTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTG
CPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASV
PEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAAH
3D structure
PDB8j6n Discovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.
ChainG
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.4.1.1: cystathionine gamma-lyase.
4.4.1.2: homocysteine desulfhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TVJ G Y60 R62 Y51 R53
BS02 TVJ G G90 Y114 E157 N161 D187 S209 T211 K212 E339 S340 T355 R375 G81 Y105 E148 N152 D178 S200 T202 K203 E330 S331 T346 R366
Gene Ontology
Molecular Function
GO:0004123 cystathionine gamma-lyase activity
GO:0005516 calmodulin binding
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
GO:0044540 L-cystine L-cysteine-lyase (deaminating)
GO:0047982 homocysteine desulfhydrase activity
GO:0080146 L-cysteine desulfhydrase activity
GO:0098606 selenocystathionine gamma-lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006749 glutathione metabolic process
GO:0008285 negative regulation of cell population proliferation
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019343 cysteine biosynthetic process via cystathionine
GO:0019344 cysteine biosynthetic process
GO:0019346 transsulfuration
GO:0030308 negative regulation of cell growth
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0044524 protein sulfhydration
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051289 protein homotetramerization
GO:0070814 hydrogen sulfide biosynthetic process
GO:1904831 positive regulation of aortic smooth muscle cell differentiation
GO:1990830 cellular response to leukemia inhibitory factor
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j6n, PDBe:8j6n, PDBj:8j6n
PDBsum8j6n
PubMed37777556
UniProtP18757|CGL_RAT Cystathionine gamma-lyase (Gene Name=Cth)

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