Structure of PDB 8imy Chain G

Receptor sequence

>8imyG (length=581) Species: 9606 (Homo sapiens) [Search protein sequence]

RRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTM
VEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFS
RKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQA
VGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQS
SPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFC
QKGGLLCTLQGKLQPEDWDGPLQGLQTLLLMVLRQASGRPHGSHGLFLRY
RVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLYLL
PGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEGVGLASLVAPLLIS
QAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNTHR
PDRGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGP
RTLYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVL
EHHTYGALLFPLLSLGLYPCWLLFWNVLFWK

3D structure

PDB

8imy Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis

Chain

Resolution

3.22 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AJP	G	Q46 Y49 L373 P376 G379	Q37 Y40 L361 P364 G367
BS02	6OU	G	A298 S299 R301 P553 T556 L557 S560 W564 L599 F600 L603	A286 S287 R289 P513 T516 L517 S520 W524 L559 F560 L563
BS03	6OU	G	S370 G372 M375 G511	S358 G360 M363 G471
BS04	Y01	G	A555 W578	A515 W538
BS05	Y01	G	L469 Y472 A473 L476 W578	L435 Y438 A439 L442 W538
BS06	MG	G	H354 Q355	H342 Q343
BS07	05E	G	H354 Q355	H342 Q343

Gene Ontology

	Molecular Function
GO:0003923	GPI-anchor transamidase activity
GO:0005515	protein binding
GO:0015631	tubulin binding
GO:0034235	GPI anchor binding

	Biological Process
GO:0006091	generation of precursor metabolites and energy
GO:0006506	GPI anchor biosynthetic process
GO:0006621	protein retention in ER lumen
GO:0008218	bioluminescence
GO:0016255	attachment of GPI anchor to protein
GO:0065003	protein-containing complex assembly

	Cellular Component
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0042765	GPI-anchor transamidase complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8imy, PDBe:8imy, PDBj:8imy
PDBsum	8imy
PubMed	37684232
UniProt	O43292\|GPAA1_HUMAN Glycosylphosphatidylinositol anchor attachment 1 protein (Gene Name=GPAA1)

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