Structure of PDB 8imx Chain G

Receptor sequence

>8imxG (length=579) Species: 9606 (Homo sapiens) [Search protein sequence]

RRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTM
VEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFS
RKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQA
VGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQS
SPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFC
QKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHGSHGLF
LRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFL
YLLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEGLASLVAPLLI
SQAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNPD
RGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGPRT
LYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVLEH
HTYGALLFPLLSLGLYPCWLLFWNVLFWK

3D structure

PDB

8imx Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis

Chain

Resolution

2.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	G	H354 Q355	H345 Q346
BS02	Y01	G	L396 H397	L387 H388
BS03	6OU	G	S299 R301 L557 S560 W564 A584 L585 L599 F600 L603	S290 R292 L515 S518 W522 A542 L543 L557 F558 L561
BS04	6OU	G	S370 I371 G372 M375 A507	S361 I362 G363 M366 A465
BS05	Y01	G	L523 G559 L563	L481 G517 L521
BS06	Y01	G	L284 Q288	L275 Q279
BS07	Y01	G	L558 L574 W578	L516 L532 W536
BS08	AJP	G	Q46 Y49 S370 G372 L373 G379	Q37 Y40 S361 G363 L364 G370
BS09	80Y	G	Y49 S51 Q355 S356 F357	Y40 S42 Q346 S347 F348

Gene Ontology

	Molecular Function
GO:0003923	GPI-anchor transamidase activity
GO:0005515	protein binding
GO:0015631	tubulin binding
GO:0034235	GPI anchor binding

	Biological Process
GO:0006091	generation of precursor metabolites and energy
GO:0006506	GPI anchor biosynthetic process
GO:0006621	protein retention in ER lumen
GO:0008218	bioluminescence
GO:0016255	attachment of GPI anchor to protein
GO:0065003	protein-containing complex assembly

	Cellular Component
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0042765	GPI-anchor transamidase complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8imx, PDBe:8imx, PDBj:8imx
PDBsum	8imx
PubMed	37684232
UniProt	O43292\|GPAA1_HUMAN Glycosylphosphatidylinositol anchor attachment 1 protein (Gene Name=GPAA1)

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