Structure of PDB 8ifl Chain G

Receptor sequence

>8iflG (length=428) Species: 1393122 (Thermoflavifilum thermophilum) [Search protein sequence]

MKELIYIEEPSILFAHGQKCTDPRDGLALFGPLNQIYGIKSGVVGTQKGL
QIFKSYLDKIQKPIYNHNNITRPMFPGFEAVFGCKWESQNIVFKEITKRT
YDLVTLFNDKIITANKNDEERVDVWFVIVPEYDAQFHDQLKARLLEHTIP
TQILRESTLAWRDFKNTFGAPIRDFSKIEGHLAWTISTAAYYKAGGKPWK
LGPGVCYLGLVYKKIQNACCAAQMFLDNGDGTVFKGEVGPWYNPEKGEYH
LKPKEAKALLTQALESYKEQNKSYPKEVFIHARTRFNDEEWNAFNEVTPK
NTNLVGVTITKSKPLKLYKTEGAFPIMRGNAYIVDEKKAFLWTLGFVPKL
QSTLSMEVPNPIFIEINKGEAEIQQVLKDILALTKLNYNACIYADGEPVT
LRFANKIGEILTASTEIKTPPLAFKYYI

3D structure

PDB

8ifl Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system.

Chain

Resolution

3.11 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	G	Y202 D203 A204 F206 H207 K211 Q222 I223 R225 T228 F245 H251 L252 T255 I256 G326 L423 S434 E436 N439 N466 N468 A469 D474 G475 R481 I507	Y132 D133 A134 F136 H137 K141 Q152 I153 R155 T158 F175 H181 L182 T185 I186 G247 L344 S355 E357 N360 N387 N389 A390 D395 G396 R402 I428
BS02	dna	G	R72 I248 Y285 K286 Y328 R362 T363 R364 F403 S431 T432	R72 I178 Y212 K213 Y249 R283 T284 R285 F324 S352 T353

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding

View graph for
Molecular Function

External links

PDB	RCSB:8ifl, PDBe:8ifl, PDBj:8ifl
PDBsum	8ifl
PubMed	37932528
UniProt	A0A1I7NFD7

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