Structure of PDB 8fwj Chain G

Receptor sequence

>8fwjG (length=552) Species: 1063 (Cereibacter sphaeroides)

GIGKSPTGIQGFDELTLGGLPTGRPSLVCGSAGCGKTLFASTFLINGVRD
HGEPGVFVTFEERPEDIVNNVASLGFELDKLIEEEKIAIEHIAVDPSEVA
EIGDYDLEGLFLRLELAIDTVGAKRVVLDTIESLFSAFSNPAILRAEIRR
LFDWLKERGLTTVITAERGDGALTRQGLEEYVSDCVILLDHRVENQISTR
RLRIVKYRGTAHGTNEYPFLIDTDGFSVLPVSALGLLHQVHEERIASGVP
DLDAMMAGGGFFRGSSILVSGVAGAGKSSLAAHFAAAACARGERAMYFSF
EEAADQAVRNMRSLGLDLGRWRDAGLLRFMATRPTFYSLEMHLAVILREV
MRFEPSVVVLDPISAFTESGDRLEVQSMLLRIVDFLKNRGITGIFTHLAH
TTDAGLEELMDGWVLMLNREVNGEFNRELYLLKARGMAHSNQVREFLMSD
RGISLLPPHLGEGGALTGTARKAEEARLRRAEIERQTELGRLQQQIEQRR
RRARAQIEALEAELQAEEIALKALVESESAHERQRLADADTLARSRGNER
FA

3D structure

• PDB: 8fwj From primordial clocks to circadian oscillators.
• Chain: G
• Resolution: 2.7 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	G	A274 G275 G277 K278 S279 S280 S314 L315 M454	A273 G274 G276 K277 S278 S279 S313 L314 M448
BS02	ADP	G	A33 G34 C35 G36 K37 T38 L39 S74 L75 R201 I222	A32 G33 C34 G35 K36 T37 L38 S73 L74 R200 I221
BS03	ATP	G	K439 A440 M443 A444 H445	K433 A434 M437 A438 H439
BS04	ADP	G	K207 T211 A212	K206 T210 A211

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

External links

• PDB: RCSB:8fwj, PDBe:8fwj, PDBj:8fwj
• PDBsum: 8fwj
• PubMed: 36949197
• UniProt: B9KWX8