Structure of PDB 8eg5 Chain G

Receptor sequence
>8eg5G (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]
FDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSD
LGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAY
DAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDV
3D structure
PDB8eg5 Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.
ChainG
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.59: caspase-6.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UCI G R64 T67 C163 R34 T37 C133
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8eg5, PDBe:8eg5, PDBj:8eg5
PDBsum8eg5
PubMed37104712
UniProtP55212|CASP6_HUMAN Caspase-6 (Gene Name=CASP6)

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