Structure of PDB 8edg Chain G

Receptor sequence

>8edgG (length=550) Species: 7370 (Musca domestica)

MDNLEVKAKINQGLYKITPRHKGTSFIWNVLADIQKEDDTLVEGWVFCRK
CEKVLKYTTRQTSNLCRHKCCASLKQSRELKTVSADCKKEAIEKCAQWVV
RDCRPFSAVSGSGFIDMIKFFIKVGAEYGEHVNVEELLPSPITLSRKVTS
DAKEKKALISREIKSAVEKDGASATIDLWTDNYIKRNFLGVTLHYHENNE
LRDLILGLKSLDFERSTAENIYKKLKAIFSQFNVEDLSSIKFVTDRGANV
VKSLANNIRINCSSHLLSNVLENSFEETPELNMPILACKNIVKYFKKANL
QHRLRSSLKSECPTRWNSTYTMLRSILDNWESVIQILSEAGETQRIVHIN
KSIIQTMVNILDGFERIFKELQTCSSPSLCFVVPSILKVKEICSPDVGDV
ADIAKLKVNIIKNVRIIWEENLSIWHYTAFFFYPPALHMQQEKVAQIKEF
CLSKMEDPVCPSDEFEFYRKEIVILSEDFKVMEWWNLNSKKYPKLSKLAL
SLLSIPASSAASERTFSLAGNIITEKRNRIGQQTVDSLLFLNSFYKNFCK

3D structure

• PDB: 8edg Zinc-finger BED domains drive the formation of the active Hermes transpososome by asymmetric DNA binding.
• Chain: G
• Resolution: 4.64 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	G	P142 T146 E584 N587 R588	P139 T143 E525 N528 R529
BS02	dna	G	K585 R586 R588 T593	K526 R527 R529 T534
BS03	dna	G	T27 S28 Q64 S66 F109 S110 R573	T24 S25 Q61 S63 F106 S107 R514
BS04	dna	G	L58 K59 Q64 H71 K72 R218 T220 A251 K255 R308 S310 T317 R318 W319 E572 S576	L55 K56 Q61 H68 K69 R215 T217 A248 K252 R305 S307 T314 R315 W316 E513 S517
BS05	dna	G	D248 R249	D245 R246
BS06	ZN	G	C51 C54 H71 C73	C48 C51 H68 C70

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0046872 metal ion binding
• GO:0046983 protein dimerization activity

Biological Process

• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:8edg, PDBe:8edg, PDBj:8edg
• PDBsum: 8edg
• PubMed: 37491363
• UniProt: Q25438