Structure of PDB 8cgs Chain G

Receptor sequence

>8cgsG (length=822) Species: 511 (Alcaligenes faecalis)

NDRITLPPANAQRTNMTCHFCIVGCGYHVYKWPELQEGGRAPEQNALGLD
FRKQLPPLAVTLTPAMTNVVTEHNGRRYNIMVVPDKACVVNSGLSSTRGG
KMASYMYTPTGDGKQRLKAPRLYAADQWVDTTWDHAMALYAGLIKKTLDK
DGPQGVFFSCFDHGGAGGGFENTWGTGKLMFSAIQTPMVRIHNRPAYNSE
CHATREMGIGELNNAYEDAQLADVIWSIGNNPYESQTNYFLNHWLPNLQG
ATTSKKKERFPNENFPQARIIFVDPRETPSVAIARHVAGNDRVLHLAIEP
GTDTALFNGLFTYVVEQGWIDKPFIEAHTKGFDDAVKTNRLSLDECSNIT
GVPVDMLKRAAEWSYKPKASGQAPRTMHAYEKGIIWGNDNYVIQSALLDL
VIATHNVGRRGTGCVRMGGHQEGYTRPPYPGDKKIYIDQELIKGKGRIMT
WWGCNNFQTSNNAQALREAILQRSAIVKQAMQKARGATTEEMVDVIYEAT
QNGGLFVTSINLYPTKLAEAAHLMLPAAHPGEMNLTSMNGERRIRLSEKF
MDPPGTAMADCLIAARIANALRDMYQKDGKAEMAAQFEGFDWKTEEDAFN
DGFRRAGQPGAPAIDSQGGSTGHLVTYDRLRKSGNNGVQLPVVSWDESKG
LVGTEMLYTEGKFDTDDGKAHFKPAPWNGLPATVQQQKDKYRFWLNNGRN
NEVWQTAYHDQYNSLMQERYPMAYIEMNPDDCKQLDVTGGDIVEVYNDFG
STFAMVYPVAEIKRGQTFMLFGYVNGIQGDVTTDWTDRNIIPYYKGTWGD
IRKVGSMEEFKRTVSFKSRRFA

3D structure

• PDB: 8cgs Arsenite oxidase in complex with antimonite and arsenite oxyanions: Insights into the catalytic mechanism.
• Chain: G
• Resolution: 1.84 Å

Enzymatic activity

• Enzyme Commision number: 1.20.9.1: arsenate reductase (azurin).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MGD	G	G170 H195 N196 W389 H423 G456 C457 N458 T462 I513 N514 L515 A530 D563 N700 R702 Q708 T709 Y711 F774 Y797	G167 H192 N193 W386 H420 G453 C454 N455 T459 I510 N511 L512 A527 D560 N697 R699 Q705 T706 Y708 F771 Y794
BS02	MGD	G	R101 G232 N233 E237 S238 D277 P278 R279 G304 D306 E384 K385 G386 G422 H423 W697 N699 G701 R702 N704 V706 W707 Q708 K798	R98 G229 N230 E234 S235 D274 P275 R276 G301 D303 E381 K382 G383 G419 H420 W694 N696 G698 R699 N701 V703 W704 Q705 K795
BS03	F3S	G	C21 C24 G27 C28 Y30 S99 R101 G102 N241	C18 C21 G24 C25 Y27 S96 R98 G99 N238
BS04	UJI	G	H195 E203 R419 G422 H423	H192 E200 R416 G419 H420

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0050611 arsenate reductase (azurin) activity
• GO:0051536 iron-sulfur cluster binding
• GO:0051538 3 iron, 4 sulfur cluster binding

Biological Process

• GO:0045333 cellular respiration

Cellular Component

• GO:1990204 oxidoreductase complex

External links

• PDB: RCSB:8cgs, PDBe:8cgs, PDBj:8cgs
• PDBsum: 8cgs
• PubMed: 37442232
• UniProt: Q7SIF4|AIOA_ALCFA Arsenite oxidase subunit AioA (Gene Name=aioA)