Structure of PDB 8cas Chain G

Receptor sequence
>8casG (length=396) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence]
QATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKI
YKCQEEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSGAAVMDA
ALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHQ
KSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISP
RLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRPGIVTIQ
CKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGA
KGHLPNIYTDIEINYFLLRRLLGVKKQAKVRKLEPNEVLMVNIGSTATGA
RVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRLIGWATIKK
3D structure
PDB8cas Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
ChainG
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna G F128 K129 E131 L132 I138 K139 R319 S320 F321 G339 R408 D410 F31 K32 E34 L35 I41 K42 R206 S207 F208 G226 R289 D291
BS02 MET G Y142 F381 E383 L395 Y45 F262 E264 L276
BS03 MG G K139 G141 K42 G44
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0031369 translation initiation factor binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0045903 positive regulation of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cas, PDBe:8cas, PDBj:8cas
PDBsum8cas
PubMed37169754
UniProtP32481|IF2G_YEAST Eukaryotic translation initiation factor 2 subunit gamma (Gene Name=GCD11)

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