Structure of PDB 8c82 Chain G

Receptor sequence
>8c82G (length=554) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TRVPLCEPEELPDDIQKENEYGTLDSPGHLYQVKSRHGKPLPEPVVDTPP
YYISLLTYLNYLILIILGHVHDFLGMTFQKNKHLDLLEHDGLAPWFSNFE
SFYVRRIKMRIDDCFSRPTTGVPGRFIRCIDRISHNINEYFTYSGAVYPC
MNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAE
KLVARFIGKEDALVFSMGYGTNANLFNAFLDKKCLVISDELNHTSIRTGV
RLSGAAVRTFKHGDMVGLEKLIREQIVLGQPKTNRPWKKILICAEGLFSM
EGTLCNLPKLVELKKKYKCYLFIDEAHSIGAMGPTGRGVCEIFGVDPKDV
DILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSESMPAPVLAQTI
SSLQTISGEICPGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPVIP
LLLYCPSKMPAFSRMMLQRRIAVVVVAYPATPLIESRVRFCMSASLTKED
IDYLLRHVSEVGDKLNLKSNSGKSSYDGKRQRWDIEEVIRRTPEDCKDDK
YFVN
3D structure
PDB8c82 Structure of the ceramide-bound SPOTS complex.
ChainG
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.50: serine C-palmitoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Z8A G I72 Y110 Y485 I65 Y103 Y478
BS02 Q7G G F80 M83 T84 F73 M76 T77
BS03 PLP G D331 H334 K366 D324 H327 K359
Gene Ontology
Molecular Function
GO:0004758 serine C-palmitoyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0009058 biosynthetic process
GO:0030148 sphingolipid biosynthetic process
GO:0046512 sphingosine biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0090156 intracellular sphingolipid homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0017059 serine palmitoyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c82, PDBe:8c82, PDBj:8c82
PDBsum8c82
PubMed37794019
UniProtP40970|LCB2_YEAST Serine palmitoyltransferase 2 (Gene Name=LCB2)

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