Structure of PDB 8b9z Chain G

Receptor sequence
>8b9zG (length=677) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
PEKIEVFVDDIPVQVVPGTTVLQAAAQIGVEIPRFCYHERLAVAGNCRMC
LVEVEKSPKPVAACAMPVMKGWRIKTNSDLTRKAREGVMEFLLMNHPLDC
PICDQGGECDLQDQAMAFGSDRSRFTDINYTGKRAVEDKDIGPLVKTIMT
RCIHCTRCVRFASEIAGVDDLGTTGRGNDMQIGTYVEKLFLTELSGNVID
LCPVGALTNKPYSFVARPWEIRKVSSIDVLDAVGSNIVVSTRTNEVLRIL
PRENEDVNEEWLADKSRFACDGLKRQRLVAPMVRMPNGELQAVEWEGALI
AVAKAIKAAGGQIAGISGQLADLEAQVALKDLLNRLGSEVVATEQGFIAG
GTDNRANYLLNSTIAGLEEADAVLLVGTNPRYEAPLVNTRLRKAYVHNEL
QIASIGPKIDLSYDHENLGADAALVKDVCSGAHAFSKVLEGAKKPAIIIG
ADLLERADGAAIHATVAEYCKKLKKPNWNPFNVLQTNAAQVGALDVGYKA
GAQTAVKAQPKVLFLLNADAGKVTREQLPKDCFVVYIGSHGDNGASIADA
VLPGAAYTEKQGIYVNTEGRPQQTLPGVSPPGMAREDWKILRALSEVVGK
PLPYDNLDELRNRLEDVAPHLTRLGQLEPAGDAGAIDIKLKELRDYFMTD
AISRASPTMAKCISAVNKQQRENEAKQ
3D structure
PDB8b9z Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster.
ChainG
Resolution3.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 G H134 D137 C138 C141 G144 C147 Q150 V242 H96 D99 C100 C103 G106 C109 Q112 V204
BS02 SF4 G C190 I191 H192 C193 T194 R195 C196 C240 A244 C152 I153 H154 C155 T156 R157 C158 C202 A206
BS03 FES G R72 C74 Y75 G83 C85 R86 C88 C102 R34 C36 Y37 G45 C47 R48 C50 C64
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0042773 ATP synthesis coupled electron transport
GO:0045333 cellular respiration
GO:0072593 reactive oxygen species metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Cellular Component
External links
PDB RCSB:8b9z, PDBe:8b9z, PDBj:8b9z
PDBsum8b9z
PubMed36622099
UniProtQ94511|NDUS1_DROME NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (Gene Name=ND-75)

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