Structure of PDB 8b6c Chain G

Receptor sequence

>8b6cG (length=233) Species: 9986 (Oryctolagus cuniculus)

VVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKV
PPAINQFTQVLDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAKRP
PVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCI
LKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEI
RRHWGGNVLGPKSVARIAKLEKAKAKELATKLG

3D structure

• PDB: 8b6c Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative.
• Chain: G
• Resolution: 2.79 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	G	E86 K87 R88 K90 F92 I94 Q96 I98 Q99 P100 K101 L104 R106 F107 K109 P111 R112 Y113 I122 L123 K125 R126 L127 K128 Q161 K163 R166 R185 G192 V193 N194 T195 T198 P216 L219 K240 A241 R249 K250 T251 T253 P297 K298 R302	E7 K8 R9 K11 F13 I15 Q17 I19 Q20 P21 K22 L25 R27 F28 K30 P32 R33 Y34 I43 L44 K46 R47 L48 K49 Q82 K84 R87 R99 G106 V107 N108 T109 T112 P130 L133 K154 A155 R163 K164 T165 T167 P211 K212 R216
BS02	rna	G	T105 Y113 I114 Q117 R118 R142 H212 D213 K238 R242	T26 Y34 I35 Q38 R39 R63 H126 D127 K152 R156

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0000470 maturation of LSU-rRNA
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8b6c, PDBe:8b6c, PDBj:8b6c
• PDBsum: 8b6c
• PubMed: 36867692
• UniProt: G1STW0|RL7A_RABIT Large ribosomal subunit protein eL8 (Gene Name=RPL7A)