Structure of PDB 7zls Chain G

Receptor sequence
>7zlsG (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSD
YLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY
VQMCKDKHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYL
EEYKFQV
3D structure
PDB7zls Structure-based design of a phosphotyrosine-masked, cell-penetrant small molecule covalently targeting Cys111 on the E3 ligase SOCS2
ChainG
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JH9 G S76 H77 S78 S47 H48 S49
BS02 JH9 G V55 K59 R73 S75 S76 T93 N94 L95 R96 L150 V26 K30 R44 S46 S47 T64 N65 L66 R67 L109
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:7zls, PDBe:7zls, PDBj:7zls
PDBsum7zls
PubMed37816714
UniProtO14508|SOCS2_HUMAN Suppressor of cytokine signaling 2 (Gene Name=SOCS2)

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