Structure of PDB 7z34 Chain G

Receptor sequence

>7z34G (length=230) Species: 559292 (Saccharomyces cerevisiae S288C)

NPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQRQKKILSIRLKVPP
TIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAVAEGKSKQ
DASPKPYAVKYGLNHVVALIENKKAKLVLIANDVDPIELVVFLPALCKKM
GVPYAIVKGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFA
DKYDEVKKHWGGGILGNKAQAKMDKRAKNS

3D structure

• PDB: 7z34 Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
• Chain: G
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	G	S29 T30 P31 K32 N33 G35 I36 G37 Q38 V40 Q41 R44 L46 S47 R48 Y49 K51 P53 E54 Y55 R60 R68 L69 E100 K105 R108 D124 S126 K128 P129 K133 Y134 G135 L136 H138 A141 L142 K147 V157 P159 K183 A184 Q192 K193 T194 S195 G239 N240 K241 K245	S6 T7 P8 K9 N10 G12 I13 G14 Q15 V17 Q18 R21 L23 S24 R25 Y26 K28 P30 E31 Y32 R37 R45 L46 E77 K82 R85 D101 S103 K105 P106 K110 Y111 G112 L113 H115 A118 L119 K124 V134 P136 K160 A161 Q169 K170 T171 S172 G216 N217 K218 K222
BS02	rna	G	V56 Q59 K63	V33 Q36 K40

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000470 maturation of LSU-rRNA
• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7z34, PDBe:7z34, PDBj:7z34
• PDBsum: 7z34
• PubMed: 36097293
• UniProt: P17076|RL8A_YEAST Large ribosomal subunit protein eL8A (Gene Name=RPL8A)