Structure of PDB 7yo1 Chain G

Receptor sequence

>7yo1G (length=879) Species: 9606 (Homo sapiens)

PCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTWMTSVKDWAGV
MISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQID
MAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSW
LGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFI
HLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLF
MVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITL
ESVSNFLKAFLHKARDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQG
SVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPK
IRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGL
STMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTV
CELCFVKLKLLMISRILINPGNGTLGFFIASDAKEVKRAFFYCKKYDSTG
MFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMP
LRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLR
AVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDTTGVNIP
IITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSAT
YFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRV
AQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQ
CTKRYVITNPPYEFELVPTDLIFCLMQFD

3D structure

• PDB: 7yo1 Structural basis for dual allosteric gating modulation of Slo1-LRRC channel complex
• Chain: G
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	G	Q889 D892 D895	Q712 D715 D718
BS02	MG	G	E374 E399	E321 E346
BS03	CA	G	N509 S512 R514 V532 N534	N456 S459 R461 V479 N481

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006813 potassium ion transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7yo1, PDBe:7yo1, PDBj:7yo1
• PDBsum: 7yo1
• UniProt: Q12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)