Structure of PDB 7xd8 Chain G

Receptor sequence

>7xd8G (length=623) Species: 11060 (dengue virus type 2)

IESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGS
ASSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEP
KEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDE
NKWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFG
KAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLG
YILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAE
AIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNME
AQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDCV
VKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHEL
IMKDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMY
FHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRV
WIQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTA
INQVRSLIGNEEYTDYMPSMKRF

3D structure

• PDB: 7xd8 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
• Chain: G
• Resolution: 2.85 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	G	K402 R404 A408 K457 I474 Y476 R482 N493 G509 G511 G602 V604 W803 M804 V812 R815	K136 R138 A142 K191 I208 Y210 R216 N227 G243 G245 G336 V338 W537 M538 V546 R549
BS02	rna	G	R404 S405 S661 D663 D664 C709 S710 L754 S757 Y758 M761 T790 S791 R792	R138 S139 S395 D397 D398 C443 S444 L488 S491 Y492 M495 T524 S525 R526
BS03	ZN	G	H712 H714 C728 C847	H446 H448 C462 C581
BS04	ZN	G	E438 H442 C447 C450	E172 H176 C181 C184

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005524 ATP binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7xd8, PDBe:7xd8, PDBj:7xd8
• PDBsum: 7xd8
• PubMed: 36577062
• UniProt: Q91H74