Structure of PDB 7wf3 Chain G

Receptor sequence
>7wf3G (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
RQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINL
FDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSR
KHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAM
YWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELF
HKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGR
RQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMEN
IGAIQVLPKLSSSIIHEIDSILGNKPYS
3D structure
PDB7wf3 Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.
ChainG
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP G G55 R189 W243 S244 P245 L246 K254 R264 G323 S325 Q329 E332 N333 G22 R156 W210 S211 P212 L213 K221 R231 G290 S292 Q296 E299 N300
Gene Ontology
Molecular Function
GO:0005249 voltage-gated potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wf3, PDBe:7wf3, PDBj:7wf3
PDBsum7wf3
PubMed35091471
UniProtQ13303|KCAB2_HUMAN Voltage-gated potassium channel subunit beta-2 (Gene Name=KCNAB2)

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