Structure of PDB 7sr6 Chain G

Receptor sequence
>7sr6G (length=432) Species: 9606 (Homo sapiens) [Search protein sequence]
PKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWN
SPVFVIQKKSGKWRMLTDLRAVNALIQPMGPLQPGLPSPAMIPKDWPLII
IDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPT
ICQTFVGRALQPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEV
ANAGLAIASDKIQTSTPFHYLGMQIENRKIKPQKIEIRKDTLKTLNDFQK
LLGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRILTPEATKEIKLVE
EKIQSAQINRIGPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVK
TFTLYLDQIATLIGQTRLRITKLCGNDPDKIVVPLTKEQVRQAFINSGAW
QIGLANFVGIIDNHYPKTKIFQFLKLTTWILP
3D structure
PDB7sr6 Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
ChainG
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG G R89 V427 G428 R70 V408 G409
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sr6, PDBe:7sr6, PDBj:7sr6
PDBsum7sr6
PubMed35771941
UniProtQ9UQG0|POK11_HUMAN Endogenous retrovirus group K member 11 Pol protein (Gene Name=ERVK-11)

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