Structure of PDB 7qzu Chain G

Receptor sequence

>7qzuG (length=423) Species: 9606 (Homo sapiens)

AFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVER
LKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAI
ALDTKGPGSGPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAAL
GPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFL
AQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADC
IMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDP
TEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQ
AARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDL
VIVVTGWRPGSGYTNIMRVLSIS

3D structure

• PDB: 7qzu Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.
• Chain: G
• Resolution: 1.964 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.40: pyruvate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FBP	G	L443 T444 T445 T446 S449 W494 R501 G526 R528 P529 G530 S531 G532 Y533 T534	L323 T324 T325 T326 S329 W374 R381 G406 R408 P409 G410 S411 G412 Y413 T414
BS02	OXL	G	K282 E284 A305 G307 D308 T340	K162 E164 A185 G187 D188 T220
BS03	MG	G	E284 D308	E164 D188
BS04	I4L	G	T62 P65 N87 S89 H90 Y95 S374 G375 A378 K379	T40 P43 N65 S67 H68 Y73 S254 G255 A258 K259

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003824 catalytic activity
• GO:0004743 pyruvate kinase activity
• GO:0030955 potassium ion binding

Biological Process

• GO:0006096 glycolytic process

External links

• PDB: RCSB:7qzu, PDBe:7qzu, PDBj:7qzu
• PDBsum: 7qzu
• PubMed: 35290845
• UniProt: P30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)