Structure of PDB 7pt7 Chain G

Receptor sequence
>7pt7G (length=683) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SAALPSIQLPVDYNNLFNEITDFLVTFKQDKGPKYMAMLQKVANRELNSV
IIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLP
TKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMNDALREVVEDE
TELFPPNLTRRYFLYFKPLSQNCAISSKPLSVRQIKGDFLGQLITVRGII
TRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTK
GQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSP
GDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTS
DVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVG
DGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTA
AVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQT
ISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFD
ILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYA
KTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRL
SQALAKLRLADMVDIDDVEEALRLVRVSKESLY
3D structure
PDB7pt7 The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.
ChainG
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP G E542 R687 E497 R642
BS02 BEF G R593 R687 R548 R642
BS03 ZN G C262 C265 C284 C289 C217 C220 C239 C244
BS04 ADP G I422 Y423 G463 V464 A465 K466 S467 Q468 I377 Y378 G418 V419 A420 K421 S422 Q423
BS05 BEF G P462 K466 N568 P417 K421 N523
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:1904931 MCM complex binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pt7, PDBe:7pt7, PDBj:7pt7
PDBsum7pt7
PubMed35614055
UniProtP38132|MCM7_YEAST DNA replication licensing factor MCM7 (Gene Name=MCM7)

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