Structure of PDB 7pt6 Chain G

Receptor sequence
>7pt6G (length=683) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SAALPSIQLPVDYNNLFNEITDFLVTFKQDKGPKYMAMLQKVANRELNSV
IIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLP
TKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMNDALREVVEDE
TELFPPNLTRRYFLYFKPLSQNCAISSKPLSVRQIKGDFLGQLITVRGII
TRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTK
GQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSP
GDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTS
DVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVG
DGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTA
AVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQT
ISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFD
ILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYA
KTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRL
SQALAKLRLADMVDIDDVEEALRLVRVSKESLY
3D structure
PDB7pt6 The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.
ChainG
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS G E542 P686 R687 L690 E497 P641 R642 L645
BS02 ADP G I422 Y423 P462 G463 V464 A465 K466 S467 Q468 L612 V616 I377 Y378 P417 G418 V419 A420 K421 S422 Q423 L567 V571
BS03 ZN G C262 C265 C284 C289 C217 C220 C239 C244
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:1904931 MCM complex binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pt6, PDBe:7pt6, PDBj:7pt6
PDBsum7pt6
PubMed35614055
UniProtP38132|MCM7_YEAST DNA replication licensing factor MCM7 (Gene Name=MCM7)

[Back to BioLiP]