Structure of PDB 7p7c Chain G

Receptor sequence

>7p7cG (length=905) Species: 469008 (Escherichia coli BL21(DE3))

ATIHVDGKEYEVNGADNLLEACLSLGLDIPYFCWHPALGSVGACRQCAVK
QYQNAEDTRGRLVMSCMTPASDGTFISIDDEEAKQFRESVVEWLMTNHPH
DCPVCEEGGNCHLQDMTVMTGHSFRRYRFTKRTHRNQDLGPFISHEMNRC
IACYRCVRYYKDYAGGTDLGVYGAHDNVYFGRPEDGTLESEFSGNLVEIC
PTGVFTDKTHSERYNRKWDMQFAPSICQQCSIGCNISPGERYGELRRIEN
RYNGTVNHYFLCDRGRFGYGYVNLKDRPRQPVQRRGDDFITLNAEQAMQG
AADILRQSKKVIGIGSPRASVESNFALRELVGEENFYTGIAHGEQERLQL
ALKVLREGGIYTPALREIESYDAVLVLGEDVTQTGARVALAVRQAVKGKA
REMAAAQKVADWQIAAILNIGQRAKHPLFVTNVDDTRLDDIAAWTYRAPV
EDQARLGFAIAHALDNSAPAVDGIEPELQSKIDVIVQALAGAKKPLIISG
TNAGSLEVIQAAANVAKALKGRGADVGITMIARSVNSMGLGIMGGGSLEE
ALTELETGRADAVVVLENDLHRHASATRVNAALAKAPLVMVVDHQRTAIM
ENAHLVLSAASFAESDGTVINNEGRAQRFFQVYDPAYYDSKTVMLESWRW
LHSLHSTLLSREVDWTQLDHVIDAVVAKIPELAGIKDAAPDATFRIRGQK
LAREPHRYSGRTAMRANISVHEPRQPQDIDTMFTFSMEGNNQPTAHRSQV
PFAWAPGWNSPQAWNKFQDEVGGKLRFGDPGVRLFETSENGLDYFTSVPA
RFQPQDGKWRIAPYYHLFGSDELSQRAPVFQSRMPQPYIKLNPADAAKLG
VNAGTRVSFSYDGNTVTLPVEIAEGLTAGQVGLPMGMSGIAPVLAGAHLE
DLKEA

3D structure

• PDB: 7p7c A universal coupling mechanism of respiratory complex I.
• Chain: G
• Resolution: 2.4 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	G	H101 D104 C105 C108 G111 C114 Q117 T205 G206	H98 D101 C102 C105 G108 C111 Q114 T202 G203
BS02	SF4	G	C153 I154 A155 C156 Y157 R158 C159 F183 C203 P204 T205 V207	C150 I151 A152 C153 Y154 R155 C156 F180 C200 P201 T202 V204
BS03	SF4	G	C230 Q232 C233 I235 C237 C265 G268 R390	C227 Q229 C230 I232 C234 C262 G265 R387
BS04	FES	G	C36 W37 G45 C47 R48 C50 C69	C33 W34 G42 C44 R45 C47 C66
BS05	CA	G	D619 Q634 E649 D733	D616 Q631 E646 D730

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0005515 protein binding
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0010181 FMN binding
• GO:0016491 oxidoreductase activity
• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0009060 aerobic respiration
• GO:0022904 respiratory electron transport chain
• GO:0042773 ATP synthesis coupled electron transport
• GO:0045333 cellular respiration
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0030964 NADH dehydrogenase complex
• GO:0045271 respiratory chain complex I
• GO:1990204 oxidoreductase complex

External links

• PDB: RCSB:7p7c, PDBe:7p7c, PDBj:7p7c
• PDBsum: 7p7c
• PubMed: 36104567
• UniProt: P33602|NUOG_ECOLI NADH-quinone oxidoreductase subunit G (Gene Name=nuoG)