Structure of PDB 7p5z Chain G

Receptor sequence
>7p5zG (length=213) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KNVEPRVTPKELLEWQTNWKKIMKRDSRIYFDITDDVEMNTYNKSKMDKR
RDLLKRGFLTLGAQITQFFDTTVTIVITRRSVENIYLLKDTDILSRAKKN
YMKVWSYEKAARFLKNLDVDLDHYFKYPHVYLYDLWQTWAPIITLEWKPQ
ELTNLDELPYPILKIGSFGRCPGYCENCRVKYESLEQHIVSEKHLSFAEN
DLNFEAIDSLIEN
3D structure
PDB7p5z Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase.
ChainG
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN G C664 H674 H680 C178 H188 H194
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0046872 metal ion binding
Biological Process
GO:0001100 negative regulation of exit from mitosis
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0007059 chromosome segregation
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0060903 positive regulation of meiosis I
GO:1901987 regulation of cell cycle phase transition
GO:1903343 positive regulation of meiotic DNA double-strand break formation
GO:1903468 positive regulation of DNA replication initiation
GO:1905561 positive regulation of kinetochore assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0031431 Dbf4-dependent protein kinase complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7p5z, PDBe:7p5z, PDBj:7p5z
PDBsum7p5z
PubMed34963704
UniProtP32325|DBF4_YEAST DDK kinase regulatory subunit DBF4 (Gene Name=DBF4)

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