Structure of PDB 7obr Chain G

Receptor sequence

>7obrG (length=241) Species: 9986 (Oryctolagus cuniculus)

KVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLK
VPPAINQFTQVLDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGK
GDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCR
KMGVPYCILKGKARLCRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTN
YNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG

3D structure

• PDB: 7obr Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle.
• Chain: G
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	G	E33 K34 K37 F39 G40 I41 G42 Q43 I45 Q46 P47 L51 R53 F54 K56 P58 R59 Y60 R62 I69 K72 R73 L74 E105 K107 Q108 K110 R113 R132 P133 G139 V140 N141 T142 P163 L166 K187 A188 R196 K197 T198 C199 T200 G243 P244 K245	E8 K9 K12 F14 G15 I16 G17 Q18 I20 Q21 P22 L26 R28 F29 K31 P33 R34 Y35 R37 I44 K47 R48 L49 E80 K82 Q83 K85 R88 R107 P108 G114 V115 N116 T117 P138 L141 K162 A163 R171 K172 T173 C174 T175 G218 P219 K220
BS02	rna	G	T52 W57 Y60 I61 Q64 R65 R67 R89 H159 D160 K185 R189	T27 W32 Y35 I36 Q39 R40 R42 R64 H134 D135 K160 R164

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0000470 maturation of LSU-rRNA

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7obr, PDBe:7obr, PDBj:7obr
• PDBsum: 7obr
• PubMed: 34260909
• UniProt: G1STW0|RL7A_RABIT Large ribosomal subunit protein eL8 (Gene Name=RPL7A)