Structure of PDB 7npa Chain G

Receptor sequence

>7npaG (length=618) Species: 523845 (Methanothermococcus thermolithotrophicus DSM 2095) [Search protein sequence]

MYEWKLNDIVDNGICAKCGTCTVVCPNGILTFEDRPKLTEECLRKGNGMC
FEVCPRVSSGKYQIKIREKFKEEYYYGKGDVEGQDGGVVTTFLKYLLKNK
KIDGAIVVGDECWKPVSLIVQNEEDLMNTTKSKYTVSTLEALKTAGEMGL
EKVAVVGLPCQINGLRKLQYFQYLAKHDGELGKNGKPVKLPKIEYLIGLL
CTEKFEYDELKETLAKYNINMDDVEKFDIKKGKLLVYVNGEEHKIPLKEI
ELSAGCKMCRDFDAEMADVSVGCVGSPDGYSTVIIRTEKGEEIKNAIELK
EGVNLEAIEKLRDLKLNRFKKEVERRKAEDEKVSFYWTADYGGVGKRADG
TYFIRIRAKPAGWYSIDEAREILEIAEKYDGKIKMTNRGAFEIHGISGFD
VEAMVLELMEKGFITGSEGPLVRATLACPGEGNCGSGLINTTELCKILED
NFKEHPAPYKFKIAISGCPNKCVRPQIHDIGIAGVKFPVVNEENCNGCGR
CAEVCKIEAIDIRGETSYTNYNVCIGCGKCIKACPNEGRDVKEEGFMVYV
GGKTGREVIEGVSMKLMSVEEILNLIDKVLIVYHKYAKKPQRERLAAVMA
RIGKGKFLEEVKELMEQN

3D structure

PDB

7npa Structures of the sulfite detoxifying F 420 -dependent enzyme from Methanococcales.

Chain

Resolution

1.55 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.8.98.3: sulfite reductase (coenzyme F420).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	G	A16 R56 P159 C160 C201 T202 K204 C256 C259 K315	A16 R56 P159 C160 C201 T202 K204 C256 C259 K315
BS02	SF4	G	C25 I29 L30 C42 R44 G46 G48 C50 E180	C25 I29 L30 C42 R44 G46 G48 C50 E180
BS03	SF4	G	P488 C505 I507 I510 C524 I525 G526 C527 G528 C530	P488 C505 I507 I510 C524 I525 G526 C527 G528 C530
BS04	SF4	G	C428 C434 S436 G437 G467 C468 N470 C472	C428 C434 S436 G437 G467 C468 N470 C472
BS05	SF4	G	C495 N496 G497 C498 G499 C501 S517 C534 N536 R539	C495 N496 G497 C498 G499 C501 S517 C534 N536 R539
BS06	FAD	G	G83 Q84 D85 G87 V88 V89 T90 V107 V108 T129 K131 S132 K133 Y134 S137 L199 L200 C201 T202 V271 G272 C273 V274 S281	G83 Q84 D85 G87 V88 V89 T90 V107 V108 T129 K131 S132 K133 Y134 S137 L199 L200 C201 T202 V271 G272 C273 V274 S281
BS07	SF4	G	C15 A16 K17 C18 G19 C21 P36 C54	C15 A16 K17 C18 G19 C21 P36 C54
BS08	SRM	G	F353 R355 K384 T386 N387 R388 E392 Y459 K460 K462 K553 T554 G555 R556 R594	F353 R355 K384 T386 N387 R388 E392 Y459 K460 K462 K553 T554 G555 R556 R594
BS09	SRM	G	C428 P429 C434 S436 N470 C472 R474 K506	C428 P429 C434 S436 N470 C472 R474 K506

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding
GO:0052592	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor

View graph for
Molecular Function

External links

PDB	RCSB:7npa, PDBe:7npa, PDBj:7npa
PDBsum	7npa
PubMed	36658338
UniProt	A0A2Z5PF12

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