Structure of PDB 7mj5 Chain G

Receptor sequence

>7mj5G (length=257) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF

3D structure

• PDB: 7mj5 Identification of a substrate-like cleavage-resistant thrombin inhibitor from the saliva of the flea Xenopsylla cheopis.
• Chain: G
• Resolution: 2.15 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	G	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 K202 P204 N205 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N164 K212 P214 N217 R218 W219
BS02	peptide	G	F34 Q38 E39 L40 H57 Y60A W60D R73 T74 Y76 I82 E97A N98 N143 Q151 R173 I174 A190 C191 E192 G193 S195 S214 W215 G216	F19 Q24 E25 L26 H43 Y47 W50 R68 T69 Y71 I78 E94 N95 N143 Q156 R178 I179 A200 C201 E202 G203 S205 S226 W227 G228

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:7mj5, PDBe:7mj5, PDBj:7mj5
• PDBsum: 7mj5
• PubMed: 34688666
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)