Structure of PDB 7kzt Chain G

Receptor sequence
>7kztG (length=577) Species: 9606 (Homo sapiens) [Search protein sequence]
CLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLP
AAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEEQG
LRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLN
GSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGL
QELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALL
YLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPAPQF
LIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLL
ALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELL
SRTSSLLPKMSRLWEDELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFS
RCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVAS
GQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQ
TLWSLPLYLESYLSWIRPSDRDAFLEE
3D structure
PDB7kzt Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
ChainG
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN G C392 E395 C499 C503 C371 E374 C472 C476
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0005515 protein binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0007005 mitochondrion organization
GO:0007286 spermatid development
GO:0009314 response to radiation
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0043240 Fanconi anaemia nuclear complex

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Cellular Component
External links
PDB RCSB:7kzt, PDBe:7kzt, PDBj:7kzt
PDBsum7kzt
PubMed33686268
UniProtO15287|FANCG_HUMAN Fanconi anemia group G protein (Gene Name=FANCG)

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