Structure of PDB 7kmf Chain G

Receptor sequence
>7kmfG (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
DKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRIQGLRANLTSAIETLC
GVDSSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLS
RNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQP
DLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGII
NKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKALKE
EHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL
3D structure
PDB7kmf Sugar phosphate activation of the stress sensor eIF2B.
ChainG
Resolution2.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6P G Y130 S131 R132 G196 E198 N208 K209 Y123 S124 R125 G189 E191 N201 K202
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0014003 oligodendrocyte development
GO:0043434 response to peptide hormone
GO:0044237 cellular metabolic process
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kmf, PDBe:7kmf, PDBj:7kmf
PDBsum7kmf
PubMed34103529
UniProtQ14232|EI2BA_HUMAN Translation initiation factor eIF2B subunit alpha (Gene Name=EIF2B1)

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