Structure of PDB 7d74 Chain G

Receptor sequence
>7d74G (length=359) Species: 9606 (Homo sapiens) [Search protein sequence]
MKALILGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVIL
AVSYMSQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETA
DPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEA
DTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLQPTSIEKEVFPIM
AKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCSGPGIV
GNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHS
WLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGE
SVPEPRIIM
3D structure
PDB7d74 Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.
ChainG
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.13: mannose-1-phosphate guanylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP G L6 G8 G11 T12 R13 K23 A52 V53 S54 P83 G85 L6 G7 G10 T11 R12 K22 A51 V52 S53 P82 G84
Gene Ontology
Molecular Function
GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0009058 biosynthetic process
GO:0009298 GDP-mannose biosynthetic process
GO:0019673 GDP-mannose metabolic process
GO:0061728 GDP-mannose biosynthetic process from mannose
GO:0141199 GDP-mannose biosynthetic process from glucose
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0120508 GDP-mannose pyrophosphorylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7d74, PDBe:7d74, PDBj:7d74
PDBsum7d74
PubMed33986552
UniProtQ9Y5P6|GMPPB_HUMAN Mannose-1-phosphate guanyltransferase beta (Gene Name=GMPPB)

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