Structure of PDB 7c41 Chain G

Receptor sequence
>7c41G (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKE
3D structure
PDB7c41 A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants.
ChainG
Resolution2.276 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP G V12 G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 V12 G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120
BS02 MG G Y32 D33 P34 Y32 D33 P34
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c41, PDBe:7c41, PDBj:7c41
PDBsum7c41
PubMed32486141
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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