Structure of PDB 7alq Chain G

Receptor sequence
>7alqG (length=192) Species: 9606 (Homo sapiens) [Search protein sequence]
PRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTK
GYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYL
PNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVE
ATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIR
3D structure
PDB7alq Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP.
ChainG
Resolution2.205 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.16: GTP cyclohydrolase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN G H144 C212 H87 C155
BS02 QBQ G N118 F122 G164 L165 S166 K167 R170 N61 F65 G107 L108 S109 K110 R113
BS03 HBI G D127 L157 V233 T240 E243 D70 L100 V176 T183 E186
BS04 QBQ G H143 H144 V181 E183 H210 R216 H86 H87 V124 E126 H153 R159
BS05 HBI G S228 R235 R241 S171 R178 R184
Gene Ontology
Molecular Function
GO:0003934 GTP cyclohydrolase I activity
Biological Process
GO:0046654 tetrahydrofolate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7alq, PDBe:7alq, PDBj:7alq
PDBsum7alq
PubMed33387654
UniProtP30793|GCH1_HUMAN GTP cyclohydrolase 1 (Gene Name=GCH1)

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