Structure of PDB 6zok Chain G

Receptor sequence

>6zokG (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVV
RISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKE
DDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTK
KNKEEAAEYAKLLAKRMKEAKEKRQEQIAK

3D structure

PDB

6zok SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	G	N4 P8 Q13 L15 R31 S53 K58 Q59 G60 Q65 R72 C83 Y84 R87 R88 G90 R92 K93 R94 K95 S96 S107 V108 N110 R132 L133 G134 K136 R137 S139 R140 R154 Q155 R159 K160 L162 K164 K167 R170 K172 P174 K175 I176 Q177 R178 V180 R183 V184 Q186 H187 K188 R189 R190 R191 K195 K196 R198 K201 N202	N4 P8 Q13 L15 R31 S53 K58 Q59 G60 Q65 R72 C83 Y84 R87 R88 G90 R92 K93 R94 K95 S96 S107 V108 N110 R132 L133 G134 K136 R137 S139 R140 R154 Q155 R159 K160 L162 K164 K167 R170 K172 P174 K175 I176 Q177 R178 V180 R183 V184 Q186 H187 K188 R189 R190 R191 K195 K196 R198 K201 N202

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019901	protein kinase binding

	Biological Process
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001890	placenta development
GO:0002181	cytoplasmic translation
GO:0002309	T cell proliferation involved in immune response
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006924	activation-induced cell death of T cells
GO:0007369	gastrulation
GO:0008284	positive regulation of cell population proliferation
GO:0022605	mammalian oogenesis stage
GO:0031929	TOR signaling
GO:0033077	T cell differentiation in thymus
GO:0042274	ribosomal small subunit biogenesis
GO:0042593	glucose homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0048821	erythrocyte development

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0030425	dendrite
GO:0032040	small-subunit processome
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0044297	cell body
GO:0048471	perinuclear region of cytoplasm
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6zok, PDBe:6zok, PDBj:6zok
PDBsum	6zok
PubMed	32908316
UniProt	P62753\|RS6_HUMAN Small ribosomal subunit protein eS6 (Gene Name=RPS6)

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