Structure of PDB 6zfh Chain G

Receptor sequence
>6zfhG (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
QPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPM
ALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPR
WANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQ
LCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRS
LETSLVPLSDPKLAVLITNSNVRSSEYPVRRRQCEEVARALGAASLREVQ
LEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVE
SHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEAS
AAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
3D structure
PDB6zfh Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
ChainG
Resolution2.439 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL G E43 H44 D46 Y47 G183 D186 Y236 G346 E38 H39 D41 Y42 G178 D181 Y227 G337
BS02 QV2 G S79 W106 Y109 S131 L135 S141 S142 L145 S74 W101 Y104 S126 L130 S136 S137 L140 BindingDB: IC50=4212.9nM
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005534 galactose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0019402 galactitol metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
GO:0046835 carbohydrate phosphorylation
GO:0061623 glycolytic process from galactose
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zfh, PDBe:6zfh, PDBj:6zfh
PDBsum6zfh
PubMed33724769
UniProtP51570|GALK1_HUMAN Galactokinase (Gene Name=GALK1)

[Back to BioLiP]