Structure of PDB 6txc Chain G

Receptor sequence

>6txcG (length=463) Species: 9606 (Homo sapiens) [Search protein sequence]

MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHL
GIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRA
YQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLT
DNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDY
ESLPKEVASAVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAI
RITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTK
PQDGDVIAPLITP

3D structure

PDB

6txc Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

2.84 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DTP	G	V156 F157 R372 H376 K377	V42 F43 R249 H253 K254
BS02	DTP	G	R333 R352 K354 N358 K523	R210 R229 K231 N235 K393
BS03	FE	G	H167 H206 D207 D311	H53 H92 D93 D188
BS04	MG	G	D207 H233	D93 H119
BS05	0KX	G	Q149 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374	Q35 R50 D93 H101 H119 D188 K189 Y192 D196 R243 Y251
BS06	GTP	G	K116 V117 I118 D137 R145	K2 V3 I4 D23 R31
BS07	GTP	G	Y155 V156 V378 R451	Y41 V42 V255 R328

External links

PDB	RCSB:6txc, PDBe:6txc, PDBj:6txc
PDBsum	6txc
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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