Structure of PDB 6r6g Chain G

Receptor sequence

>6r6gG (length=233) Species: 9986 (Oryctolagus cuniculus)

VVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKV
PPAINQFTQVLDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAKRP
PVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCI
LKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEI
RRHWGGNVLGPKSVARIAKLEKAKAKELATKLG

3D structure

• PDB: 6r6g Structural and mutational analysis of the ribosome-arresting human XBP1u.
• Chain: G
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	G	E86 R88 P89 K90 F92 I94 Q96 I98 Q99 P100 K101 L104 R106 F107 K109 P111 R112 Y113 R115 L123 K125 R126 L127 K160 Q161 K163 R166 R185 P186 A191 G192 V193 N194 T195 V214 P216 L219 K240 A241 R245 R249 K250 T251 T253 P297 K298 R302 K305	E7 R9 P10 K11 F13 I15 Q17 I19 Q20 P21 K22 L25 R27 F28 K30 P32 R33 Y34 R36 L44 K46 R47 L48 K81 Q82 K84 R87 R99 P100 A105 G106 V107 N108 T109 V128 P130 L133 K154 A155 R159 R163 K164 T165 T167 P211 K212 R216 K219
BS02	rna	G	T105 Y113 I114 Q117 R118 R142 H212 D213 K238 R242	T26 Y34 I35 Q38 R39 R63 H126 D127 K152 R156

Gene Ontology

Biological Process

• GO:0042254 ribosome biogenesis

Cellular Component

• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6r6g, PDBe:6r6g, PDBj:6r6g
• PDBsum: 6r6g
• PubMed: 31246176
• UniProt: G1STW0|RL7A_RABIT Large ribosomal subunit protein eL8 (Gene Name=RPL7A)