Structure of PDB 6plg Chain G

Receptor sequence
>6plgG (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
LRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRS
ATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLS
AAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGR
IGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITV
HTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCA
GAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVD
MV
3D structure
PDB6plg Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
ChainG
Resolution2.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.37: malate dehydrogenase.
1.1.1.399: 2-oxoglutarate reductase.
1.1.1.95: phosphoglycerate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ONS G G154 R155 I156 Y174 D175 P176 H206 T207 P208 T213 G149 R150 I151 Y169 D170 P171 H201 T202 P203 T208 BindingDB: IC50=15nM
Gene Ontology
Molecular Function
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:6plg, PDBe:6plg, PDBj:6plg
PDBsum6plg
PubMed31327531
UniProtO43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase (Gene Name=PHGDH)

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