Structure of PDB 6lwp Chain G

Receptor sequence
>6lwpG (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
PEGPELHLASQFVNEACRCVEKSSVSRNPEVPFESISASARGKELRLILS
PQEPLALVFRFGMSGSFQLVPREELPRHAHLRFYTAPLALCFVDIRRFGR
WDLGGKWQPGRGPCVLQEYQQFRENVLRNLADKAFDRPICEALLDQRFFN
GIGNYLRAEILYRLKIPPFEKARSVLEALPDLLELCHSVPKEVVQLDFAA
FRAWLRCYGMPGMSSLQDRHGRTIWFQGDPGPLA
3D structure
PDB6lwp DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
ChainG
Resolution2.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna G P2 E3 E6 K54 R78 G80 M81 R118 F120 R133 N176 Y263 R277 P1 E2 E5 K43 R60 G62 M63 R96 F98 R111 N154 Y208 R222
BS02 dna G R95 H96 I117 R118 R119 F120 R77 H78 I95 R96 R97 F98
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6lwp, PDBe:6lwp, PDBj:6lwp
PDBsum6lwp
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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