Structure of PDB 6lwb Chain G

Receptor sequence
>6lwbG (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
GQGPELHLASQFVNEACVEKSSVSRNPEVPISASARGKELRLILEPLALV
FRFGMSGSFQLVPREELPRHAHLRFYTAPPGALCFVDIRRFGRWDLGGKW
QPGRGPCVLQEYQQFRENVLRNLADKAFDRPICEALLDQRFFNGIGNYLR
AEILYRLKIPPFEKARSVLEALPDLLELCHSVPKEVVQLEDFAAFRAWLR
CYGMPGMSSLQDRHGRTIWFQGDPGPLA
3D structure
PDB6lwb DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
ChainG
Resolution2.55 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna G G2 Q3 K54 M81 R118 F120 Q168 N176 Y263 R277 G1 Q2 K38 M55 R89 F91 Q139 N147 Y202 R216
BS02 dna G H96 I117 R118 R119 F120 H70 I88 R89 R90 F91
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6lwb, PDBe:6lwb, PDBj:6lwb
PDBsum6lwb
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

[Back to BioLiP]