Structure of PDB 6ks6 Chain G

Receptor sequence

>6ks6G (length=520) Species: 559292 (Saccharomyces cerevisiae S288C)

VFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGL
VLTNDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILA
QCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLI
QASIGTKYVIHWSEKMCELALDAVKTVRKDFEIDIKRYVRVEKIPGGDVL
DSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEK
EEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCS
VLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYF
SFLDNCKESGLQKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSL
SPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGG
DPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKT
AIESACLLLRVDDIVSGVRK

3D structure

• PDB: 6ks6 An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
• Chain: G
• Resolution: 2.99 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D60 T93 T94 D458
• Catalytic site (residue number reindexed from 1): D55 T88 T89 D386

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	G	L39 P41 G92 T94 T95 T161 G476 L516 G546 Y557 E561 K566	L34 P36 G87 T89 T90 T156 G404 L444 G474 Y485 E489 K494
BS02	MG	G	D91 S158	D86 S153
BS03	AF3	G	D60 T93 T94 K162 D458	D55 T88 T89 K157 D386

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0051082 unfolded protein binding
• GO:0140662 ATP-dependent protein folding chaperone

Biological Process

• GO:0006457 protein folding

External links

• PDB: RCSB:6ks6, PDBe:6ks6, PDBj:6ks6
• PDBsum: 6ks6
• PubMed: 31492816
• UniProt: P39077|TCPG_YEAST T-complex protein 1 subunit gamma (Gene Name=CCT3)