Structure of PDB 6jrs Chain G

Receptor sequence

>6jrsG (length=3488) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD
LSICTFVLEQSLSVRALQEMLANGHRTLLYGHAILLRHSYSGMYLCCLST
SRKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSE
RYLHLSYLHVDAAFQQTLWSVAPISSAQGYLIGGDVLRLLHGECLTVPSG
EHEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTT
GKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKERKEVDGMGTSEIKYGD
SVCFIQHIGTGLWLTYQSSIQRKAIMHHEGHMDDGLNLSRSQHEESRTAR
VIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPD
EHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSVAGREAG
ESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILE
VLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGV
AVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGKKWYYELMVDH
TEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLH
LWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFEN
FNIDGLFFPVVSFSAGIKVRFLLGEFKFLPPPGYAPCYEAVLPKEKLKVE
HSREYKQERTYTRDLLGPTVSAFTPIPVDTSQIVLPPHLERIREKLAENI
HELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLET
LKTLLALGCHVGISDEHAYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAE
NAHNVWARDRIRQRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYN
LEARFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGS
DERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGE
ILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTIC
GLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSSHEHIEVTRIDVTQKSF
GSQNSSTDIMFYRLSMPIECTYYYSVRIFPNVWVGWITSDFHQYDTAFDL
VTVTLGDEKGKVHESIKRSNYMVCANNGLEIGCVVGLLTFTANGKDLSTY
YQVEPSTKLFPAVFAQATSPNVFQFEAGLFKSEHKNPVPQCPPRLHVQFL
SHVLWSRMPNQFLKVDVSRISERQGWLVQCLEPLQFMSLHIPEENRSVDI
LELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIEN
KYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPD
PGIGLSTSLRPRMQFSSPSFVSINNECYQYSPEFPLDILKAKTIQMLTEA
VQEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEP
SGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQ
RFRYNEVMQALCPCPEEIRDQLLDFHEDLMTHCGIELDLTIRGRLLSLVE
KVTYTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRAL
PKTYTINGVSVEDTINLLASLGQIRSLLSVEEEKLMIRGLGDIMNNKVFY
QHPNLMRALGMHETVMEVMVNVLGPKMVANCCRFLCYFCRISRQNQKAMF
DHLSYLLENSSVTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLP
VEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPEGLLAAMEEAIKIG
NAIMTFYAALIDLLGRCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGV
ISIAFQFCPDHKAAMVLFLDRVYVQDFLLHLLEVGFLPDLRAAASLTDMA
LALNRYLCTAVLPLLLFAGTEHHASLIDSLLHTVKGCSLTKAQRDSIEVC
LLSPSMMQHLLRRLVFDVPLLNKMPLKLLTNHYERCWKYYCLPGGASEEE
LHLSRKLFWGIFDALYEQELFKLALPCLSAVAGALPNFNPQPVDTSNITI
PEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLL
SEKEKEIYRWPIKESLKTMLAWGWRIERTREGDAAHGYSPRAIDMSNVTL
SRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDTLTAKEKA
KDREKAQDILKFLQINGYAVSRGYFLSAASRPLCSGGHASNKEKEMVFCK
LGVLVRHRISLFGNDATLHILGQTLDARTVMKTGLESVKFLDNAAEDLEK
TMENLKQGQFTTTVALLPMLSSLFEHIGQHQFLEDVQVSCYRILTSLYAL
GVERQRSALGECLAAFAGAAFLETHLDKHNIYSLLSKQRKRAVVACFRMA
PLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPRVDPLHQLI
LLFSRTALTEKCKLEEDFLYMAYADIMAKSCSFEEKEMEKQKLLYQQARL
HDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLEYL
KEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGGSGEKVLQDDEFT
CDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESIS
DFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLA
HSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSML
EGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYD
PDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKR
FHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRI
EIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKM
ELFVNFCEDTIFEMQLAAQIIAYQQKLLNYFARNFYNMRMLALFVAFAIN
FILLFYKVVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLV
IFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKF
VKRKVMDKYGEFYGRDRISELLGNSIDVKYQMWKLGVVFTDNSFLYLAWY
MTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLA
VVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGG
GIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRD
QQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYL
INKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYE

3D structure

• PDB: 6jrs Modulation of cardiac ryanodine receptor 2 by calmodulin.
• Chain: G
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	G	C4889 C4892 H4909 H4914	C3413 C3416 H3433 H3438
BS02	CA	G	E3923 T4932	E2786 T3456
BS03	ATP	G	K4170 M4885 F4890 T4910 L4916	K3033 M3409 F3414 T3434 L3440
BS04	CFF	G	F3715 W4646 I4927 Y4945	F2583 W3197 I3451 Y3469

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Mon Nov 25 13:10:24 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6jrs', asym_id = 'G', title = 'Modulation of cardiac ryanodine receptor 2 by calmodulin.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6jrs', asym_id='G', title='Modulation of cardiac ryanodine receptor 2 by calmodulin.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6jrs', asym_id = 'G'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6jrs', asym_id='G')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>