Structure of PDB 6ivx Chain G

Receptor sequence
>6ivxG (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWE
MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRM
CRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSED
EIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAK
LPPAGKLASLCSQHVERLQIFQHLHPI
3D structure
PDB6ivx Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
ChainG
Resolution2.35 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G I328 V332 L353 K354 S477 E481 Q484 I63 V67 L88 K89 S212 E216 Q219
BS02 AYO G L287 C320 H323 M365 A368 V376 F377 F378 I400 F401 L22 C55 H58 M100 A103 V111 F112 F113 I135 F136
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ivx, PDBe:6ivx, PDBj:6ivx
PDBsum6ivx
PubMed30776227
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

[Back to BioLiP]