Structure of PDB 6iso Chain G

Receptor sequence
>6isoG (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPPYPEAIFELPFFFHN
PKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSG
IPASKLVEAHGTFASATCTVQRPFPGEDIRADVMADRVPRCPVCTGVVKP
DIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVP
RLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQR
ETGKL
3D structure
PDB6iso Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.
ChainG
Resolution2.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P155 N229 D231 H248
Catalytic site (residue number reindexed from 1) P35 N91 D93 H110
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G V292 F293 F294 G295 E296 P297 E323 E325 W353 V153 F154 F155 G156 E157 P158 E184 E186 W214
BS02 CRD G F180 I230 H248 F42 I92 H110
BS03 ZN G C256 V258 C118 V120
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6iso, PDBe:6iso, PDBj:6iso
PDBsum6iso
PubMed25369635
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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